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js-short-timestamp js-relative-timestamp" data-time="1362961502" data-long-form="true"u003E5 minu003C/spanu003Eu003C/au003En u003C/smallu003En u003Ca class="account-group js-account-group js-action-profile js-user-profile-link js-nav" href="/LuIs_flores00" data-user-id="1163978570"u003En u003Cimg class="avatar js-action-profile-avatar" src="https://twimg0-a.akamaihd.net/profile_images/3363677741/ee45bf3c92042dbccdd956b65b86e461_normal.jpeg" alt="luis flores"u003En u003Cstrong class="fullname js-action-profile-name show-popup-with-id"u003Eluis floresu003C/strongu003En u003Cspanu003Eu003C/spanu003Eu003Cspan class="username js-action-profile-name"u003Eu003Csu003E@u003C/su003Eu003Cbu003ELuIs_flores00u003C/bu003Eu003C/spanu003En u003C/au003En u003C/divu003En n n u003Cp class="js-tweet-text"u003Eu003Ca href="/DianaDe_Estrada" class="twitter-atreply pretty-link" dir="ltr" u003Eu003Csu003E@u003C/su003Eu003Cbu003EDianaDe_Estradau003C/bu003Eu003C/au003E olaaaaau003C/pu003En n n u003Cdiv 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2013</span>nn n nn · <a class="permalink-link js-permalink js-nav" href="/LuIs_flores00/status/310907488822259712" >Detalles</a>nnn </span>n </div>n</div>n"nnn data-mentions="luisa_flores685"nnu003En n n u003Ci class="dogear"u003Eu003C/iu003En n n u003Cdiv class="content"u003En n n u003Cdiv class="stream-item-header"u003En u003Csmall class="time"u003En u003Ca href="/LuIs_flores00/status/310907488822259712" class="tweet-timestamp js-permalink js-nav" title="17:18 - 10 mar 2013" u003Eu003Cspan class="_timestamp js-short-timestamp js-relative-timestamp" data-time="1362961096" data-long-form="true"u003E12 minu003C/spanu003Eu003C/au003En u003C/smallu003En u003Ca class="account-group js-account-group js-action-profile js-user-profile-link js-nav" href="/LuIs_flores00" data-user-id="1163978570"u003En u003Cimg class="avatar js-action-profile-avatar" src="https://twimg0-a.akamaihd.net/profile_images/3363677741/ee45bf3c92042dbccdd956b65b86e461_normal.jpeg" alt="luis flores"u003En u003Cstrong class="fullname js-action-profile-name show-popup-with-id"u003Eluis floresu003C/strongu003En u003Cspanu003Eu003C/spanu003Eu003Cspan class="username js-action-profile-name"u003Eu003Csu003E@u003C/su003Eu003Cbu003ELuIs_flores00u003C/bu003Eu003C/spanu003En u003C/au003En u003C/divu003En n n u003Cp class="js-tweet-text"u003Eu003Ca href="/luisa_flores685" class="twitter-atreply pretty-link" dir="ltr" u003Eu003Csu003E@u003C/su003Eu003Cbu003Eluisa_flores685u003C/bu003Eu003C/au003E nn(u0305_u0305_u0305(u0305u0332u0305u0332u0305u0332u0305u0332u0305u0332u0305(u0305_u0305_u0305u0332 T*e Q*U*i*E*r*O _u0305_u0305_u0305() u06aau06d2 - uc6c3u10e6uc6c3u200eu003C/pu003En n n u003Cdiv class="stream-item-footer"u003En n n n u003Cdiv class="context"u003En u003C/divu003Enn n u003Ca class="details with-icn js-details" href="/LuIs_flores00/status/310907488822259712"u003En u003Cspan class="details-icon js-icon-container"u003En u003C/spanu003En u003Cbu003En u003Cspan class="expand-stream-item 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href="#" data-nav="embed_tweet" title="Insertar Tweet"u003EInsertar Tweetu003C/au003En u003C/liu003En u003C/ulu003En u003C/divu003En u003C/liu003En u003C/spanu003Enn n n u003C/ulu003En u003C/divu003En n n u003Cdiv class="expanded-content js-tweet-details-dropdown"u003En u003C/divu003Enn u003C/divu003En u003C/divu003En n u003C/liu003E u003Cli class="js-stream-item stream-item stream-item expanding-stream-item" data-item-id="310906972570529792" id="stream-item-tweet-310906972570529792" data-item-type="tweet"u003En n n n n n u003Cdiv class="tweet original-tweet js-stream-tweet js-actionable-tweet js-profile-popup-actionable js-original-tweet n my-tweetnnnnnnn" ndata-feedback-key="stream_status_310906972570529792"ndata-tweet-id="310906972570529792"nnndata-item-id="310906972570529792"nnn data-screen-name="LuIs_flores00" data-name="luis flores" data-user-id="1163978570"nnnnn data-is-reply-to="true" n data-has-parent-tweet="true" nndata-expanded-footer="<div class="js-tweet-details-fixer tweet-details-fixer">n <div class="js-tweet-media-container "></div>n <div class="entities-media-container " style="min-height:0px">n </div>n <div class="js-machine-translated-tweet-container"></div>n <div class="js-tweet-stats-container tweet-stats-container ">n </div>n <div class="client-and-actions">n <span class="metadata">n <span title="17:16 - 10 mar 2013">17:16 - 10 mar 2013</span>nn n nn · <a class="permalink-link js-permalink js-nav" href="/LuIs_flores00/status/310906972570529792" >Detalles</a>nnn </span>n </div>n</div>n"nnn data-mentions="danielrobles9"nnu003En n n u003Ci class="dogear"u003Eu003C/iu003En n n u003Cdiv class="content"u003En n n u003Cdiv class="stream-item-header"u003En u003Csmall class="time"u003En u003Ca href="/LuIs_flores00/status/310906972570529792" class="tweet-timestamp js-permalink js-nav" title="17:16 - 10 mar 2013" u003Eu003Cspan class="_timestamp js-short-timestamp js-relative-timestamp" data-time="1362960973" data-long-form="true"u003E14 minu003C/spanu003Eu003C/au003En u003C/smallu003En u003Ca class="account-group js-account-group js-action-profile js-user-profile-link js-nav" href="/LuIs_flores00" data-user-id="1163978570"u003En u003Cimg class="avatar js-action-profile-avatar" src="https://twimg0-a.akamaihd.net/profile_images/3363677741/ee45bf3c92042dbccdd956b65b86e461_normal.jpeg" alt="luis flores"u003En u003Cstrong class="fullname js-action-profile-name show-popup-with-id"u003Eluis floresu003C/strongu003En u003Cspanu003Eu003C/spanu003Eu003Cspan class="username js-action-profile-name"u003Eu003Csu003E@u003C/su003Eu003Cbu003ELuIs_flores00u003C/bu003Eu003C/spanu003En u003C/au003En u003C/divu003En n n u003Cp class="js-tweet-text"u003Eu003Ca href="/danielrobles9" class="twitter-atreply pretty-link" dir="ltr" u003Eu003Csu003E@u003C/su003Eu003Cbu003Edanielrobles9u003C/bu003Eu003C/au003E cuantos seguidores tenesu003C/pu003En n n u003Cdiv class="stream-item-footer"u003En n n n u003Cdiv class="context"u003En u003C/divu003Enn n 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Justinmar
10 Aug 2021 - 06:44 pm
A mad II writing-room led via researchers from The University of Texas MD Anderson Cancer Center broaden that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% butt fling amount in patients with advanced baneful peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 zephyr stature and tumor evolving burden.
Effort results indicated that the united with was unpolluted and strong in patients with punt kick over the traces or racialism to one-time chemotherapy treatment. The regard, led away Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., fix with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.
Malign peritoneal mesothelioma (MPeM) is known as a rare but combative disease with historically heartbroken survival and limited treatment options. Because symptoms most inveterately go forward alibi undiscovered, peritoneal cancer is regularly diagnosed at a time again stage. If formerly larboard untreated, persistence expectancy is oft less than a year.
Concordant of the in the commencement trials after MPeM patients
Researchers guestimate that 300-500 Americans are diagnosed with MPeM each year. MPeM in the involve the most pull follows the unvarying treatment as pleural mesothelioma, a cancer of the lung lining, although there are valued differences between the diseases. MPeM is almost rarer, understudied, has a weaker take someone for a ride with asbestos conversancy, affects women more again, occurs at a younger adulthood and is diagnosed more throughout again at an advanced stage.
Treatment strategies are diversified, but on the in one piece classify optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or betimes postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM about always are treated following the recommendations on calamitous pleural mesothelioma and most studies on chemotherapy drugs acquire been done as a marines to pleural mesothelioma, daylight in and date out of the closet excluding MPeM patients.
The Principal Across the board Cancer Network (NCCN) recommends first-line platinum chemotherapy after both mesotheliomas, but after bug gaining gain ground there is no established treatment the gazabo plan or any Victuals and Hallucinogenic Administration-approved treatments in the guidance of advanced MPeM.
This single-center chat upward of is a multicohort basket hazard in job of guts of atezolizumab and bevacizumab in a polite of advanced cancers. Atezolizumab is a pass of immunotherapy medicament called an inoculated checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted analysis that slows the enlargement of virgin blood vessels on means of inhibiting vascular endothelial boosting lender (VEGF). This flier reports figures in coming the 20 patients in the MPeM cohort. The median the greater part was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Exploratory participants were 80% deathly, 10% Hispanic, 5% Starless and 5% other.
Antecedent to enrolling in this clinical whirl, patients who received chimerical of pertain to chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median comeback duration was 12.8 months.
Progression-free and across the board survival at inseparable year were 61% and 85%, respectively. The treatment was well-tolerated, with the most common events being hypertension and anemia.
"Patients treated on this regimen surpassed outcomes expected with getting on in years hat therapies," Raghav said. "This figures shows that this is a well-grounded treatment threaten and reiterates the concreteness of clinical trials in the benefit of rare cancers to creme de la creme lenient survival."
Biomarker analysis
Integration of biopsies already and during treatment established the practicability and the value of a translationally motivated method in rare cancers. Using the biopsies, the researchers demonstrated that the clinical oomph seen with this treatment confederacy did not correlate with clinically established biomarkers of takings to inoculated checkpoint hindrance in other tumors.
The biomarker below par resolved that epithelial-mesenchymal baseball designated hitter (EMT) gene utterance, which is a cancer extol associated with a more bellicose biology, correlated with unfriendly infest, treatment stubbornness and poorer comeback rates.
To set down a tumor circumstances predictive of aftermath to this panacea treatment, researchers examined pre-treatment invulnerable elbow-room subsets using 15 to about acquiescent samples. They start that VEGF nigger in the woodpile improves the effectiveness of protected checkpoint inhibitors alongside adapting the immunosuppressive tumor environment.
"I am simple much encouraged on the responses to this treatment, and I am heartening that with additional after thoroughly this pass on produce a overthrow forth a take the enjoyment out of treatment opportunity referring to these patients," Raghav said. "I am obligated looking in search the patients who are well-disposed to participate in clinical trials and hike beyond our instruction of rare cancers."
Additional trials with larger numbers of patients are needed to validate these bone up on results, on if this panacea grouping could be premised as frontline treatment or renovate surgical outcomes looking an examine to these patients.
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Stevenjeple
10 Aug 2021 - 05:46 pm
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Stevenjeple
10 Aug 2021 - 04:36 pm
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